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Abstract
Brugada syndrome, refers to a primary channelopathy, characterized by an electrocardiographic pattern that in the right precordial leads and increases the probability of developing a ventricular arrhythmia or an episode of sudden cardiac death in a structurally normal heart. Brugada syndrome primarily affects sodium channels through mutations in the SCN5A gene; however, new mutations that affect calcium and potassium channels have been discovered. Most patients with the Syndrome are asymptomatic, however, the person can debut with a major cardiac episode (sudden death or ventricular fibrillation) which makes this a life-threatening condition, forcing health professionals to anticipate these events, stratifying the risk in an appropriate manner. The cornerstone in the management of Brugada syndrome remains the implantation of an ICD, however, new pharmacological therapies continue to be developed however they need to be proven.
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References
Cerrone M. Controversies in Brugada syndrome. Trends in Cardiovascular Medicine. 2018 05;28(4):284-292. https://doi.org/10.1016/j.tcm.2017.11.003
Sieira J, Brugada P. The definition of the Brugada syndrome. European Heart Journal. 2017 08 31;38(40):3029-3034. https://doi.org/10.1093/eurheartj/ehx490
Letsas KP, Asvestas D, Baranchuk A, Liu T, Georgopoulos S, Efremidis M, Korantzopoulos P, Bazoukis G, Tse G, Sideris A, Takagi M, Ehrlich JR. Prognosis, risk stratification, and management of asymptomatic individuals with Brugada syndrome: A systematic review. Pacing and Clinical Electrophysiology. 2017 Nov 15;40(12):1332-1345. https://doi.org/10.1111/pace.13214
Gehshan JM, Rizzolo D. Understanding Brugada syndrome. Journal of the American Academy of Physician Assistants. 2015 06;28(6):32-36. https://doi.org/10.1097/01.jaa.0000465217.11857.ab
Adler A. Brugada syndrome. Current Opinion in Cardiology. 2016 01;31(1):37-45. https://doi.org/10.1097/hco.0000000000000238
Curcio A, Santarpia G, Indolfi C. The Brugada Syndrome ― From Gene to Therapy ―. Circulation Journal. 2017;81(3):290-297. https://doi.org/10.1253/circj.cj-16-0971
Sieira J, Dendramis G, Brugada P. Pathogenesis and management of Brugada syndrome. Nature Reviews Cardiology. 2016 09 15;13(12):744-756. https://doi.org/10.1038/nrcardio.2016.143
Mashar, M., Kwok, A. J., Pinder, R., & Sabir, I. (2014). The Brugada syndrome revisited. Trends in Cardiovascular Medicine, 24(5), 191–196. https://doi.org/10.1016/j.tcm.2013.11.00
Kline J, Costantini O. Inherited Cardiac Arrhythmias and Channelopathies. Medical Clinics of North America. 2019 09;103(5):809-820. https://doi.org/10.1016/j.mcna.2019.05.001
Tomé G, Freitas J. Induced Brugada syndrome: Possible sources of arrhythmogenesis. Revista Portuguesa de Cardiologia. 2017 Dec;36(12):945-956. https://doi.org/10.1016/j.repc.2017.06.015
Gourraud J, Barc J, Thollet A, Le Marec H, Probst V. Brugada syndrome: Diagnosis, risk stratification and management. Archives of Cardiovascular Diseases. 2017 03;110(3):188-195. https://doi.org/10.1016/j.acvd.2016.09.009
Polovina MM, Vukicevic M, Banko B, Lip GY, Potpara TS. Brugada syndrome: A general cardiologist's perspective. European Journal of Internal Medicine. 2017 Oct;44:19-27. https://doi.org/10.1016/j.ejim.2017.06.019
De Oliveira Neto NR, de Oliveira WS, Mastrocola F, Sacilotto L. Brugada phenocopy: Mechanisms, diagnosis, and implications. Journal of Electrocardiology. 2019 07;55:45-50. https://doi.org/10.1016/j.jelectrocard.2019.04.017
Coppola G, Corrado E, Curnis A, Maglia G, Oriente D, Mignano A, Brugada P. Update on Brugada Syndrome 2019. Current Problems in Cardiology. 201908; 100454. https://doi.org/10.1016/j.cpcardiol.2019.100454
Pappone C, Santinelli V, , . Brugada Syndrome: Progress in Diagnosis and Management. Arrhythmia & Electrophysiology Review. 2019;8(1):13. https://doi.org/10.15420/aer.2018.73.2