Abstract
Thromboembolic venous disease is positioned within the main causes of mortality in the hospitalized patient. This condition, which includes deep venous thrombosis and pulmonary embolism, can lead to serious complications and increase in health expenses. However, its prevention has demonstrated to be effective and safe in reducing venous thromboembolic events in patients with risk factors. There are several models for risk assessment of these events that define which patients require thromboprophylaxis; as well as, bleeding scales that discourage the use of pharmacological therapy and recommend mechanical methods. Evidence recommends which therapy is the most appropriate according to the context in which the clinician is involved.
Keywords
References
Pfeifer S, Butts S, Dumesic D, Fossum G, Gracia C, La Barbera A, Mersereau J, Odem R, Penzias A, Pisarska M, Rebar R, Reindollar R, Rosen M, Sandlow J, Sokol R, Vernon M, Widra E. Combined hormonal contraception and the risk of venous thromboembolism: a guideline. Fertility and Sterility. 2017 01;107(1):43-51. https://doi.org/10.1016/j.fertnstert.2016.09.027
Di Nisio M, Carrier M, Lyman GH, Khorana AA. Prevention of venous thromboembolism in hospitalized medical cancer patients: guidance from the SSC of the ISTH. Journal of Thrombosis and Haemostasis. 2014 09 22; 12(10): 1746-1749. https://doi.org/10.1111/jth.12683
Barbar S, Prandoni P. Scoring Systems for Estimating Risk of Venous Thromboembolism in Hospitalized Medical Patients. Semin Thromb Hemost. 2017; 43(5): 460-468. https://www.doi.org/10.1055/s-0036-1597901
Spyropolus AC, Raskob GE. New paradigms in venous thromboprophylaxis of medically ill patients. Thromb Haemost. 2017; 117:1-9. https://www.doi.org/10.1160/TH17-03-0168
Hansrani V, Khanbhai M, McCollum C. The Prevention of Venous Thromboembolism in Surgical Patients. Adv Exp Med Biol. 2017; 906:1-8. https://www.doi.org/10.1007/5584_2016_100
Leavitt AD, Minichiello T. Current Medical Diagnosis & Treatment. 58 ed. New York: McGraw-Hill; 2019. p573-588.
Weitz JI. Harrison’s Principles of Internal Medicine. 20ed. New York: McGraw-Hill; 2018. p843-855.
Gazitúa R, Saavedra S, Conte G, Figueroa G. Tromboprofilaxis en pacientes médicos hospitalizados. ¿A todos por igual? Rev Hosp Clin Univ Chile [internet]. 2015 [citado 02-02-2019]; 26:185-197. Disponible en: https://www.redclinica.cl/Portals/0/Users/014/14/14/tromboprofilaxis_pacientes_hospitalizados.pdf
Kahn SR, Morrison DR, Diendéré G, Piché A, Filion KB, Klil-Drori AJ, Douketis JD, Emed J, Roussin A, Tagalakis V, Morris M, Geerts W. Interventions for implementation of thromboprophylaxis in hospitalized patients at risk for venous thromboembolism. . Cochrane Database of Systematic Reviews. 2018 04 24;. https://doi.org/10.1002/14651858.cd008201.pub3
Schünemann HJ, Cushman M, Burnett AE, Kahn SR, et al. American Society of Hematology 2018 guidelines for management of venous thromboembolism: prophylaxis for hospitalized and non hospitalized medical patients. Blood advances. 2018; 2(22): 3198-3225. https://www.doi.org/10.1182/bloodadvances.2018022954
Carrier M, Abou-Nassar K, Mallick R, Tagalakis V, et al. Apixaban to Prevent Venous Thromboembolism in Patients with Cancer. N Engl J Med. 2019; 380(8): 711-719. https://www.doi.org/10.1056/NEJMoa1814468
Thrombosis Canada. Thromboprophylaxis: Hospitalized medical patients. Thrombosis Canada [internet]. 2017 [citado 02-02-2019]; 1-3. Disponible en: https://thrombosiscanada.ca/clinicalguides/
Cohen A, Harrington R, Goldhaber, S, Hull R, et al. Extender Thromboprophylaxis with Betrixaban in Acutely Ill Medical Patients. N Engl J Med. 2016; 375(6): 534-544. https://www.doi.org/10.1056/NEJMoa1601747
Barraza-Zetina A. Tromboprofilaxis en cirugía de columna. Revisión de la práctica actual. Revista Mexicana de Anestesiología [internet]. 2018 [citado 02-02-2019]; 41(1): 45-53. Disponible en: https://www.medigraphic.com/pdfs/rma/cma-2018/cma181i.pdf
Figueroa G, Labarca E, Cornejo R, et al. Recomendaciones de la Sociedad Chilena de Medicina Intensiva para la Prevención del Tromboembolismo Venoso en Pacientes Críticos Médico-Quirúrgicos Adultos. Revista Chilena de Medicina Intensiva [internet]. 2016 [citado 02-02-2019]; 31(3):162-174. Disponible en: https://www.medicina-intensiva.cl/revistaweb/revistas/indice/2016_3/pdf/3.pdf
Dennis M, Caso V, Kappelle LJ, et al. European Stroke Organisation (ESO) guidelines for prophylaxis for venous thromboembolism in immobile patients with acute ischaemic stroke. European Stroke Journal. 2016; 1(1):6-19. https://www.doi.org/10.1177/2396987316628384
Arabi Y, Al-Hameed F, Burns K, et al. Adjunctive Intermittent Pneumatic Compression for Venous Thromboprophylaxis. N Engl J Med. 2019; 380(14):1305-1315. https://www.doi.org/10.1056/NEJMoa1816150